>hisA-Schizosaccharomyces [Schizosaccharomyces pombe] (Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces; pombe)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------MEKSQHTLFRPCIDI--
--HQGQ--VKQIVG------GTLGNDADVKTN--YVSLKPSSYYAELYKL-NHLEGAHVI
MLGP---------NCEEAAKTALHTW---PGALQIGGGI-NISNAQNW-----------L
Q-EGASKVIVTSWLFP-DAQFDLD-------------RLKAISSKIGKDRLVVDVSCRRK
D------------------------NRWFAAINKWQVM----TAFELNEENLDLLSQYC-
SEFLIHAADVEGLCKGIDEDLVIKLGEWV----KIPTTYAGGGRSIEDLDLVDKL---SK
GKVDLTIGSALD-IFGGVLEFTRVVA---WNRRFTPLPLQD-------
>hisA-Saccharomyces [Saccharomyces cerevisiae (baker's yeast)] (Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces; cerevisiae)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MTKFIGCIDL--
--HNGE--VKQIVG------GTLTSKKEDVPKTNFVSQHPSSYYAKLYKD-RDVQGCHVI
KLGP---------NNDDAAREALQES---PQFLQVGGGI-NDTNCLEW-----------L
K--WASKVIVTSWLFTKEGHFQLK-------------RLERLTELCGKDRIVVDLSCRKT
Q-----------------------DGRWIVAMNKWQTL----TDLELNADTFRELRKYT-
NEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDEL---SH
GKVDLTFGSSLDIFGGNLVKFEDCCR--WNEKQG--------------
>hisF-Pseudomonas1 [Pseudomonas aeruginosa] (Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; aeruginosa)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MVRRRVIPCLLL--
--KDRG--LVKTVK--------FKEPKYVGD---------PINAIRIFNE-KEVDELILL
DIDA---SRLNQEPNYELIAEVAGEC---FMPICYGGGIKTLEHAEKI-----------F
S-LGVEKVSINT-----AALMDLS-------------LIRRIADKFGSQSVVGSIDCRKG
F-----------------------WGGHSVFSENGTRD----MKRSPLEWAQALEEAGV-
GEIFLNSIDRDGVQKGFDNALVENIASNV----HVPVIACGGAGSIADLIDLFER---TC
--VSAVAAGSL--FVFHGKHRAVLIS--YPDVNKLDVG----------
>hisF-Campylobacter1 [Campylobacter jejuni] (Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae; Campylobacter; jejuni)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLKTRIIPCVLL--
--KNSQ--LVKSIE--------FKDFRTIGH---------LTSTMRIYNA-RNVDELIIL
DIDA---SKSG-EIDFESIEDLAKEC---FMPLTIGGGIKTLEDIQKI-----------L
N-LGADKISINS-----KALEDMD-------------FISKAGNRFGSQCIVCSIDVKRK
G------------------------DQFCVYDRGNL------LEKSPLELALEYEKKGA-
GELLLTSVDFEGKAKGYDLELLKIFQNKL----KIPLIINGGLSKPSDGVEALNL---G-
--ADALAGAYI--FHFSKYTPKDVKE--ELARQGFAVRLL--------
>hisF-Schizosaccharomyces [Schizosaccharomyces pombe] (Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces; pombe)
MIVSIVDYGSGNVRSLINAVRYLGFETQWIRNPHDIEKAECLIFPGVGNFGFVCDSLAKQ
GFLEPLRRYALSGKPFMAVCVGIQALFEGSVEAPHSKGLGVFPGLVQRFDNDDKTVPHIG
WNSCAVRSDTSKEFFGMRPHDKFYFVHSYMIPEKGLILPPEFKIATTKYGNETFVGAIVK
NNFLATQFHPEKSGSAGLRCLKAFLTGNYEQPISGEASKLIENSFGGLTKRIIACLDV-R
SNDAGDLVVTKGDQYDVREKSSGSEVRNLGK---------PVELCQRYFQ-EGADEVVFL
NITSFRNCPMADAPMLQVLEKAAQTV---FVPLTVGGGIRDVSDPDGTFHPAVEVAGIYF
R-SGADKVSIGS-----DAVYAAEKYYENGKKLSGKTAIETISKAYGNQAVVISVDPKRQ
YVKVPEDTKHHVVKTSRLGPNGEAYCWYQCTVKGGREY----RDIDVVELTRACEAMGA-
GEVLLNCMDQDGSNAGYDIELVRLVKNSV----NIPVIASSGAGIPQHFEEVFKE---TD
--CDAALAAGI--FHRQTCRIEDVKE--YLAIHDVLVRT---------
>hisF-Xylella [Xylella fastidiosa] (Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xylella; fastidiosa)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLSRRLIPCLDV--
--RDGR--VVKGVK--------FRDHVDMGD---------IVELALRYRD-HGADELVFY
DIGA---SPRGRSVDYRWVERVARLI---DIPFCVAGGIGQVETARAV-----------L
H-AGADKISINS-----PALRQPA-------------LISALAEAFGVQCVVVGIDSIRE
A-----------------------DGQWRVRCNTGDPDKTQALPLRTLDWIVEAQRLGA-
GEIVLNCMDSDGVRCGYDIAQLSQARALC----QVPLVASGGAGNMQHFADVFHK---AD
--VDGALAASV--FHSGAILIPGLKQ--FLREQQIEVRDV--------
>hisF-Buchnera [Buchnera aphidicola (Acyrthosiphon pisum)] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera; aphidicola)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIACLDV--
--DDGV--VVKGIK--------FQNHKIVGD---------IVPLARRYAK-EGIDELVFY
DITA---ATKNKLVDRSWIKNVSKVI---NIPFCVAGGIKSVEDAKKV-----------L
S-SGADKISINS-----SALIDPN-------------LITKISERFGVQCVVIGIDSWFD
K----------------------TKNSYMVQQYTGDISKTYQTSWKTSDWVKKVQEKGA-
GEIVLNMMNKDGLQKGYDISHLSEIRKIC----KVPLIASGGAGSVEHFYEALYY---SN
--VDGVLAASV--FHKNIVEIKVLKK--KLIARGMEIREC--------
>hisF-Campylobacter2 [Campylobacter jejuni] (Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae; Campylobacter; jejuni)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLTKRIIACLDV--
--KDGR--VVKGTQ--------FKNHKDMGD---------IIELARYYSQ-NGIDELVFY
DIAA---SARKERISREWVSEVAKNI---NISFCVAGGIKSEEDAAEL-----------L
A-NGADKISINS-----PALNDPS-------------LITRLAKSFGVQCVVVGIDSFKD
E-----------------------NGNLKVFQYTGDEKTSKHSGKSTLEWVKKVQDLGA-
GEIVLNMMNQDGVKNGYDLEQLEAVYKIC----KVPLIASGGAGKMEHFLEAFKL---G-
--IDGALAASV--FHQKLIDIKELKI--YLKNQGLSIRI---------
>hisF-Haemophilus [Haemophilus influenzae] (Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus; influenzae)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDV--
--RDGQ--VVKGVQ--------FRNHEIIGD---------IVPLAQRYAQ-EGADELVFY
DITA---SSDGRTVDKSWVERIAQVI---DIPFCVAGGIKTIEDAEKL-----------F
A-FGADKISINS-----PALADPT-------------LISRLADRFGVQAIVVGIDSWFE
Q----------------------ETGKYWVNQYTGDETRTRQTHWQLLDWVKEVQQCGA-
GEIVLNMMNQDGLRNGYDLAQLKLVRGVC----RVPLIASGGAGKMVHFRDAFIE---AK
--VDGALAASV--FHKQIIEIGELKS--YLVQSAIEIRSE--------
>hisF-Pasteurella [Pasteurella multocida] (Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Pasteurella; multocida)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDV--
--RDGQ--VVKGVQ--------FRNHEIIGD---------IVPLAQRYAE-EGADELVFY
DITA---SSDGRTIDKSWVERVAQVI---DIPFCVAGGIKSVEDAEKL-----------F
A-FGADKISINS-----PALADPD-------------LINRLADRFGVQAIVVGIDSWFE
K----------------------ETGKYWVNQYTGDESRTRQTHWQLLDWVKEVQQRGA-
GEIVLNMMNQDGVRQGYDIAQLKLVRNLC----HIPLIASGGAGEMVHFRDAFIE---AN
--VDGALAASV--FHKRIIDIGELKD--YLRKEKIKIR----------
>hisF-Vibrio [Vibrio cholerae] (Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; cholerae)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDV--
--RDGQ--VVKGVQ--------FRNHEIIGD---------IVPLAKRYAE-EGADELVFY
DITA---SSDGRVVDKSWVARVAEVI---DIPFCVAGGIKSAQDAARI-----------L
E-FGADKVSINS-----PALANPQ-------------LITDLADRFGVQCIVVGIDSYFD
K----------------------ETGQYQVYQFTGDESRTRATQWQTCDWVQEVQKRGA-
GEIVLNMMNQDGVRNGYDLEQLNLVRSVC----RVPLIASGGAGAMEHFAQAFTQ---AN
--VDGALAASV--FHKQIINIGELKQ--YLKQQGIEVRR---------
>hisF-Yersinia [Yersinia pestis] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Yersinia; pestis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDV--
--KDGQ--VVKGVQ--------FRNHEIIGD---------IVPLAQRYAQ-EGADELVFY
DITA---SSDGRVVDKSWVARVAEVI---DIPFCVAGGIKSVEDASQI-----------L
T-FGADKISINS-----PALADPT-------------LITRLADRYGVQCIVVGIDTWYD
T----------------------ESDSYQVYQFTGDEKRTKATTWQTEDWVKEVQLRGA-
GEIVLNMMNQDGVRNGYDLRQLQQMRAIC----HVPLIASGGAGTPDHFLEAFRD---AD
--VDGALAASV--FHKQIINIGELKK--YLSEQGVEIRVC--------
>hisF-Escherichia [Escherichia coli] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia; coli)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDV--
--RDGQ--VVKGVQ--------FRNHEIIGD---------IVPLAKRYAE-EGADELVFY
DITA---SSDGRVVDKSWVSRVAEVI---DIPFCVAGGIKSLEDAAKI-----------L
S-FGADKISINS-----PALADPT-------------LITRLADRFGVQCIVVGIDTWYD
A----------------------ETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA-
GEIVLNMMNQDGVRNGYDLEQLKKVREVC----HVPLIASGGAGTMEHFLEAFRD---AD
--VDGALAASV--FHKQIINIGELKA--YLATQGVEIRIC--------
>hisF-Salmonella [Salmonella typhimurium] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella; typhimurium)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDV--
--RDGQ--VVKGVQ--------FRNHEIIGD---------IVPLAKRYAD-EGADELVFY
DITA---SSDGRVVDKSWVARVAEVI---DIPFCVAGGIRSIDDAAKI-----------L
S-FGADKISINS-----PALADPT-------------LITRLADRFGVQCIVVGIDTWFD
D----------------------ATGKYHVNQYTGDENRTRVTQWETLDWVQEVQQRGA-
GEIVLNMMNQDGVRNGYDLTQLKKVRDVC----RVPLIASGGAGTMEHFLEAFRD---AD
--VDGALAASV--FHKQIINIGELKA--YLAGQGVEIRIC--------
>hisF-Staphylococcus [Staphylococcus aureus subsp. aureus Mu50] (Bacteria; Firmicutes; Bacillales; Staphylococcus; aureus)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MIKKRIIPCLDV--
--KDGR--VVKGIQ--------FKGLRDIGN---------PVDLAIYYNE-AGADELVFL
DISK---TEEGHSLMLEVIEQTASRL---FIPLTVGGGIQSLDDITQL-----------L
N-HGADKVSLNS-----SALKNPQ-------------LIKQASDKFGRQCICIAIDSYYD
P----------------------ERKAHYCCTHGGKKM----TNIKVYDWVQQVEQLGA-
GELLVTSMGHDGMKQGFDIEHLAKIKSLV----NIPIIASGGGGNAQHFVELFNQ---TD
--VSAGLAASI--LHDRETTVQSIKE--VIRQGGIAVR----------
>hisF-Halobacterium [Halobacterium salinarum] (Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Halobacterium; salinarum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MTLTKRVIPCIDVDL
D-DDGEPAVYTGVN--------FEELAYTGD---------PVEMAKRYNE-AGADEFVFL
DITA---SAEGRETMLDTVSAVADEV---FIPLTVGGGIRDTDDIRET-----------L
R-AGADKVSINS-----GAIADPS-------------LVDRGAKAFGSQCIVISVDARRR
F----------DEQGQHYTQVDGESCWFECTVHGGREG----TGMDAIEWVQEAQRRGA-
GELFVNSIDADGTQDGYDVPLTAAVCDAV----STPVIASSGCGAPGDMADAYDA---G-
--ADAALAASI--FHFDEYSIAETKE--TLADAGYPIRAPDA------
>hisF-Deinococcus [Deinococcus radiodurans R1] (Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae; Deinococcus; radiodurans)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MLRGVLAKRIVPCLDV--
--QNGR--VVKNVR-------FFEDHRDAGD---------PLVLAQAYEA-QQADELVFY
DITA---THEGRSLMLDVAARVAEQV---MMPLTVGGGVGALSDFRQL-----------L
L-AGADKISVNS-----GAVKRPE-------------LIREASDHYGAQCVMLSIDAKRR
P----------------------GGQGWTVHIGGGRVD----TGLDLLAWARRGQELGA-
GELCLNVMDADGTRAGFDLEATRAVAREV----DLPVIASGGAGKVQDFYDVLTA---GE
--ADAALAASV--FHFGELTVPQVKT--SLAAQGVPVRPEWRGATE--
>hisF-Lactococcus [Lactococcus lactis subsp. lactis] (Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus; lactis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLTKRIIPCLDI--
--KNGK--VVKGIN--------FVSLREIGD---------SVELAKIYEE-QCADEIVFL
DITA---SFEEREIIGELIGRAAREL---SIPLTFGGGIRSIDDFRRI-----------L
A-RGADKVSVNS-----AAIENPE-------------LIRQAANELGVQCVVVAIDAKKR
A----------------------DHRGYDVYIKGGREN----AGLDLVDWAKKCERLGA-
GEILLTSMDKDGTKTGYDLEMLNDVCTAV----NIPVVASGGCGKISDIVEVFQN---TR
--SDAALVASL--FHYGEATVDEVKD--ELIKNNIPARIIKKETL---
>hisF-Sulfolobus [Sulfolobus solfataricus] (Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfolobus; solfataricus)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MTTKRIIACLDV--
--KDGN--VVKGVN--------FLNLQLKGD---------PVSLASLYEE-EGADEIVFL
DITA---TIEARKALYNVIKDTASVL---SIPLTVGGGIRTPDDVSMA-----------L
R-SGADKVSINT-----AAVESSQ-------------IVKKSAEEFGSQAVVVAIDVKKV
S------------------------GNWIVFTKSGTYN----TRLDAIKWAKKVEELGA-
GEILLTSIDRDGTRLGYDLELTRKIVDSV----NIPVIASGGAGKMEHFYEVFSL---AK
--ADAALAAGI--FHDGIIKIKDLKS--YLSQKGIEVRM---------
>hisF-Corynebacterium [Corynebacterium glutamicum] (Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium; glutamicum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MGVAIRVIPCLDV--
--DNGR--VVKGVN--------FENLRDAGD---------PVELAKRYDE-EGADELTFL
DVTA---SKHGRGTMLDVVRRTADQV---FIPLTVGGGVRSEEDVDQL-----------L
R-AGADKVSVNT-----SAIARPE-------------LLSELSKRFGAQCIVLSVDARRV
P-----------------EGGTPQPSGFEVTTHGGSKS----AELDAIEWAKRGEELGV-
GEILLNSMDGDGTKNGFDLELLEKVRAAV----SIPVIASGGAGKAEHFPPAVAA---G-
--ANAVLAATI--FHFREVTIAEVKG--AIKDAGFEVRK---------
>hisF-Mycobacterium1 [Mycobacterium leprae] (Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; leprae)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MYSGNGLAVRVIPCLDV--
--YCGR--VVKGVN--------FKNLRDAGD---------LVELAAAYDA-EGADELAFL
DVTA---SSSGRATMLEVVRCTAEQV---FIPLMVGGGVRTVADVDVL-----------L
R-AGADKVAVNT-----AAIARPE-------------LLADMAGQFGSQCIVLSVDARTV
P-----------------TGSARTPSGWEATTHGGYRG----TGIDAVEWAARGADLGV-
GEILLNSMDADGTKAGFDLAMLRAVRAAV----TVPVIASGGAGAIEHFVPAVTA---G-
--ADAVLAASV--FHFRELTIGQVKD--AMAAAGIAVR----------
>hisF-Mycobacterium2 [Mycobacterium tuberculosis] (Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; tuberculosis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------MYADRDLPGAGGLAVRVIPCLDV--
--DDGR--VVKGVN--------FENLRDAGD---------PVELAAVYDA-EGADELTFL
DVTA---SSSGRATMLEVVRRTAEQV---FIPLTVGGGVRTVADVDSL-----------L
R-AGADKVAVNT-----AAIACPD-------------LLADMARQFGSQCIVLSVDARTV
P-----------------VGSAPTPSGWEVTTHGGRRG----TGMDAVQWAARGADLGV-
GEILLNSMDADGTKAGFDLALLRAVRAAV----TVPVIASGGAGAVEHFAPAVAA---G-
--ADAVLAASV--FHFRELTIGQVKA--ALAAEGITVR----------
>hisF-Methanothermobacter [Methanothermobacter thermautotrophicus str. Delta H] (Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter; thermautot.)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MSSGLFQMRRNMFYVDSDTSELLMAIEMLAKRIIPCLDCDL
QVPNGR--VVKGVE--------FKQIRYAGD---------PVELATRYYE-DGADEIVFL
DITA---SHERRETMTHVIEATTENV---FVPICVGGGIRKPEDYFKM-----------L
K-AGADKCSTNT-----AAIKNPE-------------LINEASDLVGSQACVVAIDAKRR
Y-----IENPRESDERFIIEVDDGYCWYECSIYGGREF----TGIDAVKWAMECQDRGA-
GEILLTSMDRDGTKMGYDIPLTRTMSENL----DIPVIASGGVGEPEHIYEAFTD---GK
--ADAALAASI--FHFNEYPVPAVKE--YLRSRGVPIRL---------
>hisF-Pyrobaculum [Pyrobaculum aerophilum] (Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae; Pyrobaculum; aerophilum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MDVALRIIPCLDI--
DGKAGV--VVKGVN--------FQGIREVGD---------PVEMAVRYEE-EGADEIAIL
DITA---APEGRATFIDSVKRVAEAV---SIPVLVGGGVRSLEDATTL-----------F
R-AGADKVSVNT-----AAVRNPQ-------------LVALLAREFGSQSTVVAIDAKWN
G------------------------EYYEVYVKGGREA----TGLDAVKWAKEVEELGA-
GEILLTSIDRDGTGLGYDVELIRRVADSV----RIPVIASGGAGRVEHFYEAAAA---G-
--ADAVLAASL--FHFRVLSIAQVKR--YLKERGVEVRI---------
>hisF-Nostoc [Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)] (Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc; sp.)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLSKRILPCLDV--
--KAGR--VVKGVN--------FVDLKDAGD---------PVELAKVYND-AGADELVFL
DITA---THEDRDTIIDVVYRTAEQV---FIPLTVGGGIQSLENVKAL-----------L
R-AGADKVSINS-----AAVRDPE-------------LIDRASDHFGNQCIVVAIDARRR
V--------------------DPSNPGWDVYVRGGREN----TGLDALSWAKEVEKRGA-
GELLVTSMDADGTQAGYDIELTRAIAESV----EIPVVASGGAGNCEHIYTALTE---GK
--AEAALLASL--LHYGQLSVAEIKN--YLHESQVPVRLYTQF-----
>hisF-Synechocystis [Synechocystis sp. PCC 6803] (Bacteria; Cyanobacteria; Chroococcales; Synechocystis; sp.)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MTLAKRILPCLDV--
--NAGR--VVKGIN--------FVDLQDAGD---------PVELARAYNE-AGADELVFL
DITA---THEQRDTIIDVVYRTAEEV---FIPLTVGGGISTLEHIKNL-----------L
R-AGADKVSVNS-----SAVRDPD-------------FISRASDRFGRQCIVVAIDARRR
L--------------------DADNPGWDVYVRGGREN----TGLDAIAWAEEVAKRGA-
GELLVTSMDGDGTQAGYDLALTAAIAERV----EIPVIASGGAGNCQHVYEAFTE---GK
--AEAALLASL--LHYGQLTIGELKT--FLEARQIPVRHTAVCG----
>hisF-Methanopyrus [Methanopyrus kandleri] (Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae; Methanopyrus; kandleri)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MALAKRIIPCLDV--
--KDGR--VVKGVR--------FRGLRDAGD---------PAELAHHYYR-HGADEIVFL
DISA---SPEGRRLMVDVVRRTAEKV---FIPMTVGGGISDVEDFRRA-----------L
T-AGADKVSVNT-----AAVENPE-------------LISEAADIFGSQCVVVAIDAKRE
P-----LKPEHEHVADHIFSNDDGEYWFRVYVRGGREP----VDLDAITWAKRVEELGA-
GEILLTSIDADGTQEGYDIELTREVCNAV----SIPVIASGGCGHPKHMVEVFKE---AD
--ADAALAASI--FHYGKFTIEEVKE--HLAERGVRVRQC--------
>hisF-Neisseria1 [Neisseria meningitidis serogroup A] (Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria; meningitidis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MALAKRIIPCLDV--
--KDGR--VVKGVN--------FIGLRDAGD---------PVEAAKRYNG-EGADELTFL
DITA---SSDNRDTILHIIEEVAGQV---FIPLTVGGGVRTVADIRRL-----------L
N-AGADKVSINT-----AAVTRPD-------------LIDEAAGFFGSQAIVAAVDAKAV
N---------------------PENTRWEIFTHGGRNP----TGLDAVEWAIEMQKRGA-
GEILLTGMDRDGTKQGFNLPLTRAVAEAV----DIPVIASGGVGNVRHLIEGITE---GK
--ADAVLAAGV--FHFGEIAIREAKH--AMREAGIEVRL---------
>hisF-Neisseria2 [Neisseria meningitidis serogroup B] (Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria; meningitidis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MALAKRIIPCLDV--
--KDGR--VVKGVN--------FIGLRDAGD---------PVEAAKRYNG-EGADELTFL
DITA---SSDNRDTILHIIEEVAGQV---FIPLTVGGGVRTVADIRRL-----------L
N-AGADKVSINT-----AAVTRPD-------------LIDEAAGFFGSQAIVAAVDAKAA
N---------------------PENTRWEIFTHGGRNP----TGLDAVEWAVEMQKRGA-
GEILLTGMDRDGTKQGFNLPLTRAVAEAV----DIPVIASGGVGNVRHLIEGITE---GK
--ADAVLAAGI--FHFGEIAIREAKR--AMREAGIEVRL---------
>hisF-Pseudomonas2 [Pseudomonas aeruginosa] (Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; aeruginosa)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MALAKRIIPCLDV--
--DNGR--VVKGVK--------FENIRDAGD---------PVEIARRYDE-QGADEITFL
DITA---SVDGRDTTLHTVERMASQV---FIPLTVGGGVRSVQDIRNL-----------L
N-AGADKVSINT-----AAVFNPE-------------FVGEAADRFGSQCIVVAIDAKKV
S-------------------APGEAPRWEIFTHGGRKP----TGLDAVLWAKKMEDLGA-
GEILLTSMDQDGVKSGYDLGVTRAISEAV----NVPVIASGGVGNLEHLAAGILE---GK
--ADAVLAASI--FHFGEYTVPEAKA--YLASRGIVVR----------
>hisF-Ralstonia [Ralstonia solanacearum] (Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Ralstonia; solanacearum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDV--
--TNGR--VVKGVN--------FVELRDAGD---------PVEIARRYDE-QGADEITFL
DITA---TSDGRDLILHIIEAVASQV---FIPLTVGGGVRALEDVRRL-----------L
N-AGADKISMNS-----SAVANPQ-------------LVSDASARHGAQCIVVAIDAKKV
S-------------------ADGEPPRWEVFTHGGRKA----TGLDAVAWAREMARRGA-
GEILLTSMDRDGTKSGFDLELTRAVSDAV----PVPVIASGGVGNLQHLADGIKL---GH
--ADAVLAASI--FHYGEHTVGEAKR--FMAQQDIPVRM---------
>hisF-Caulobacter [Caulobacter vibrioides (Caulobacter crescentus)] (Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales; Caulobacteraceae; Caulobacter; vibrioides)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLKTRIIPCLDV--
--KDGR--VVKGVN--------FVSLRDAGD---------PVEQARAYDA-AGADELMFL
DITA---SSEGRGLILDVISRTAEVC---FMPVSVGGGVRQVSDMRRL-----------L
L-AGADKVSVNT-----AAVENPD-------------LIAGGADAFGSQCVVVAIDAKAR
E----------------------DGSGWNVWTYGGRKD----TGIDVVEWAAKVVERGA-
GEILLTSMDRDGAKIGYDIPLLQAVTGAV----NVPVIASGGAGKTEHLIEAARE---GH
--AAAVLAASI--FHFGEISIGEAKQ--AMADAGIPVRLDALKGAA--
>hisF-Agrobacterium [Agrobacterium tumefaciens str. C58] (Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium; tumefaciens)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MTLKARIIPCLDV--
--KDGR--VVKGVN--------FVDLIDAGD---------PVEAAKAYDA-AGADELCFL
DITA---SSDNRDTIFDVVSRTADHC---FMPVTVGGGVRSVADIRKL-----------L
L-CGADKVSINS-----AAVKDPD-------------FVAQAADKFGNQCIVVSIDAKRV
S-------------------KDGEADRWEIFTHGGRQP----TGIDAVEFAIKMVERGA-
GELLVTSMDRDGTKSGYDIGLTRSIADQV----RVPVIASGGVGTLDDLVAGVRD---GH
--ATAVLAASI--FHFGTYSIGEAKS--YMAEHGIAMRLD--------
>hisF-Mesorhizobium [Mesorhizobium loti] (Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Mesorhizobium; loti)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLKARVIPCLDV--
--KDGR--VVKGVN--------FVDLIDAGD---------PVEAAKAYDA-AGADELCFL
DITA---SSDNRETIFDVIARTAEQC---FMPLTVGGGVRQVADIRKL-----------L
L-AGADKVSINT-----AAVKNPD-------------FVAEAADKFGNQCIVVAIDAKKV
S-------------------GAGEADRWEIFTHGGREK----TGIDAVEFARKMVDRGA-
GEILLTSMDRDGTKAGYDIALTRAIADAV----RAPIIASGGVGTLDHLVEGIRD---GH
--AGAVLAASI--FHFGTYTIAQAKA--HMAAAGLPMRLDSSGDRP--
>hisF-Brucella [Brucella melitensis] (Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella; melitensis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MTLKARVIPCLDV--
--KDGR--VVKGVN--------FVDLIDAGD---------PVEAARAYDA-AGADELCFL
DITA---SSDNRETIFDVVARTAEQC---FMPLTVGGGVRQVADIRKL-----------L
L-AGADKVSINT-----AAVKNPE-------------FVAEAADKFGNQCIVVAIDAKKV
S-------------------GAGENDHWEIFTHGGRQP----TGIDAVEFAQKVVDLGA-
GEILLTSMDRDGTKAGYDVALTRAVADSV----RAPVIASGGVGTLDHLVAGIRD---GH
--ATAVLAASI--FHFGTYTIGEAKR--YMAEAGIPMRLDPVR-----
>hisF-Sinorhizobium [Sinorhizobium meliloti (Rhizobium meliloti)] (Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium; meliloti)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MTLKARVIPCLDV--
--KDGR--VVKGVN--------FVDLIDAGD---------PVEAARAYDA-AGADELCFL
DITA---SSDNRETIFDVVARTAEQC---FMPLTVGGGVRQVADIRKL-----------L
L-AGADKVSINT-----AAVKNPE-------------FVAEAADKFGDQCIVVAIDAKKV
S-------------------AQGEADRWEIFTHGGRQP----TGIDAIEFARKVVDLGA-
GEILLTSMDRDGTKSGYDISLTRAIADAV----RAPVIASGGVGTLDHMVEGIRD---GH
--ATAVLAASI--FHFGTYSIGEAKR--HMAKHGIAMRLD--------
>hisF-Bacillus1 [Bacillus halodurans] (Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; halodurans)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLTKRIIPCLDV--
--KDGR--VVKGVQ--------FVDLRDAGD---------PVELAAFYDE-QGADELVFL
DISA---SHEGRETMIDVVEKVAGTL---AIPFTVGGGINSLEDMKRV-----------L
R-AGADKVSLNT-----AAVTRPE-------------LITEGADYFGSQCIVVAIDAKYD
E----------------------ALGSWRIYTHGGRTP----TEWEVCDWAREAVRRGA-
GEILLTSMDQDGAKTGFDLALTTKVSEAV----SVPVIASGGAGAKEDFVDVFMN---AY
--ADAALAASI--FHYKETSVAEVKT--HLREEGVAVR----------
>hisF-Bacillus2 [Bacillus subtilis] (Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; subtilis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MITKRIIPCLDV--
--KEGR--VVKGIQ--------FLELKDAGD---------PVELAEVYDR-EGADELVFL
DISA---SHEGRKTMVDVVEQVAAKL---AIPFTVGGGINQLSDMKTI-----------L
R-AGADKVSVNT-----AAVLRPE-------------LITEGAEFFGSQCIVLAIDAKYD
K----------------------ESDTYKVYTHGGRKK----TDWEVTAWAKEGVKRGA-
GEILLTSMDSDGEKKGFDHTLTKLVSEAV----PVPVIASGGAGNAQHMLEAFTK---GE
--ADAALAASI--FHYKETSIKEVKS--YLKEYGVNVR----------
>hisF-Clostridium [Clostridium acetobutylicum] (Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; acetobutylicum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLTKRIIPCLDV--
--DMGR--VVKGVN--------FVNLKDVGD---------PVEIADFYNR-EGADEIVFL
DISA---TNEGRNTMIDVVRRTAEKV---FIPLTVGGGIRDVDDFKNI-----------L
R-AGADKISINS-----AAIRNPE-------------LINEAAKKFGSQCVVVAVDARRN
I----------------------ETGGFNVFINGGRVD----TSLDAIEWVKKCESLGA-
GEILLTSMDADGTKNGYDVELTGAVCDAV----RIPVIASGGCGRLEDFDEIFKK---TS
--ADAALVASL--FHYKEYTVGEVKN--YLRENSIQVRL---------
>hisF-Listeria [Listeria innocua] (Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria; innocua)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLTKRIIPCLDV--
--TAGR--VVKGVN--------FVSLTDVGD---------PVEIAKAYNE-AGADELVFL
DITA---TVELRQTMIDVVERTAEQV---FIPLTVGGGINSVNDMKEL-----------L
Q-AGADKISLNS-----AAIKRPE-------------LIQEGANKFGNQCIVVAIDAKWN
G------------------------SNWHVFTRGGRDD----TGLDAIEWAKKATQLGA-
GEILLTSMDGDGTKNGYDIPLTKAISEAV----SVPVIASGGCGNASHMVEVFEQ---TN
--ATAALAASI--FHYGELSIKNVKT--TLLEKGVNIRP---------
>hisF-Methanocaldococcus [Methanocaldococcus jannaschii] (Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus; jannaschii)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLTKRIIPCLDI--
--KDGR--VVKGTK--------FLNLRDAGD---------PVELAQYYDD-EGADELVFL
DITA---SAEKRDIIIDVVERTAEKV---FIPLTVGGGIKSIEDFRRI-----------L
R-AGADKVSINT-----AAVKNPN-------------LIKEASEIFGSQCVVVAIDAKRH
Y----VNEDEIDKINKNVVKVEDGYCWFEVYIYGGRKE----TGIDAINWAKKVEELGA-
GEILLTSIDKDGTKSGYDLILTKEISKSV----KLPVIASGGCGKPEHVYEAFVY---GK
--ADAALMAGI--LHYREYTIEEIKK--YCADRGIPMRLL--------
>hisF-Aquifex [Aquifex aeolicus] (Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex; aeolicus)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDV--
--DKGR--VVKGVK--------FLNLRDAGD---------PVEVAKRYEE-EGADELVFL
DITA---SAEDREIMIDVVKKVAETV---FMPFTVGGGIRSLEDMRRL-----------L
E-AGADKISINT-----AAVKNPN-------------LIYEGAKRFGSQCIVVAIDAKRK
G------------------------NSWEVYIHGGRTP----TGLDAVEWAKKVESLGA-
GEILLTSMDRDGTKDGYDIELNRAISEAV----NIPVIASGGAGKKEHFYEVFSK---TK
--VEAALAASV--FHFREISIPELKE--YLLERGINVRPLD-------
>hisF-Archaeoglobus [Archaeoglobus fulgidus] (Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus; fulgidus)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLAKRIIPCLDVTL
DESEAR--VVKGVE--------FVNLRDAGD---------PVELAKRYDE-EGADELVFL
DITA---SPEGRRTMIDVIERTAEQV---FIPFTVGGGIKSIEDINTI-----------L
S-AGADKVSINT-----AAVKNPE-------------FVREAADIFGSQCIVVAIDCRRN
F--------DLSKGEYIVELEDGTKAWYEVVIYGGRKP----VGIDAVWWAKRVEELGA-
GEILLTSMNRDGTKDGFDIPITRKISEEV----NIPVIASGGAGTKEHFYEGFVE---GK
--ADACLAASI--FHYREIGIREIKE--YLAERGVQVRL---------
>hisF-Methanosarcina [Methanosarcina acetivorans] (Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; acetivorans)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MLTKRIIPCLDVTL
DRAGGC--VVKGVE--------FVDLKEAGD---------PVELAKRYNE-DGADELVFL
DITA---SAHGRETMIDVIERTADEV---FIPLTVGGGISSIDAIRQI-----------L
R-AGADKVSVNT-----SAVKNPD-------------FIKESSDIFGAQCIVTAIDCRRN
T------DIKNNPDKTVLELEDGTPAWYEVVIYGGREA----TGIDAVQWAKKAEELGS-
GEILLTSMDRDGTCAGYDLPITRKLSEEL----DIPIIASGGVGNPQHIYEGFSE---GK
--ADAALAASI--FHFSEYSIWEVKE--YLREREIPVRL---------
>hisA-Pyrobaculum [Pyrobaculum aerophilum] (Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae; Pyrobaculum; aerophilum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MIIPSIDI--
--EGGR--AVKRIR------GQRGNYIFQGD---------PLELAARFRK---APLVHVV
DLDG---AEAGGLVNISVISKIAEIL---EGRCELGGGLRSLEAVERA-----------L
S--LCQYAVVGS-----LPFKNWP-------------LFRRAAELY-RDRLAVSLDYR--
--------------------------GGEVLVGGWREK-----AASIAEAVRRLEEAGPY
AAVIVTSVEVEGTGGGVKADIDVKSLKRI----ARRVFYAGGVRDCNDVERAYAL---G-
--FDGVIVGYA--LYAGDLKKCANWY----------------------
>hisA-Sulfolobus [Sulfolobus solfataricus] (Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfolobus; solfataricus)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MNEIIPSIDI--
--SFGK--AVKRIR------GVRGTGLVLGN---------PIELANKLYN-EGYSRIHVV
DLDA----AEGVGNNEMYIKEICKIG---FDWIQVGGGIRDVEKAKRL-----------I
S-LDVNALIFST-----IVFTNFN-------------LFYNIVREIGNNRVIVSIDYD--
-------------------------DTKRVLISGWKER-----SMEIIDGIKKVNELEL-
LGIILTYVTNEGTVKGIDYSV-KDYAKLI----RGVKEYAGGVSSDSDITFLKNV---G-
--FDYIIVGMA--FYLNKIRGTNVV-----------------------
>hisA-Thermotoga [Thermotoga maritima] (Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga; maritima)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MLVVPAIDL--
--FRGK--VARMIK------GRKENTIFYEKD--------PVELVEKLIE-EGFTLIHVV
DLSN---AIENSGENLPVLEKLSEFA----EHIQIGGGIRSLDYAEKL-----------R
K-LGYRRQIVSS-----KVLEDPS-------------FLKSLREI--DVEPVFSLDTR--
--------------------------GGRVAFKGWLAE----EEIDPVSLLKRLKEYGL-
EEIVHTEIEKDGTLQEHDFSLTKKIAIEA----EVKVLAAGGISSENSLKTAQKVHTETN
GLLKGVIVGRA--FLEGILTVEVMKR--YAR-----------------
>hisA-Staphylococcus [Staphylococcus aureus subsp. aureus Mu50] (Bacteria; Firmicutes; Bacillales; Staphylococcus; aureus)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MIELWPAIDL--
--IGST--SVRLTE------GKYDSEEKMSRS--------AEESIAYYSQFECVNRIHIV
DLIG---AKAQYAREFDYIKSLRRLT---TKDIEVGGGIRTKSQIMDY-----------F
A-AGINYCIVGT-----KGIQDTD-------------WLKEMAHTF-PGRIYLSVDAY--
--------------------------GEDIKVNGWEED----TELNLFSFVRQLSDIPL-
GGIIYTDIAKDGKMSGPNFELTGQLVKAT----TIPVIASGGIRHQQDIQRLASL---N-
--VHAAIIGKA--AHQASF--WEGLE----------------------
>hisA-Xylella [Xylella fastidiosa] (Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xylella; fastidiosa)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MNFIVYPALDI--
--RNGA--VVRLQQ------GDYARQTRYDDQ--------VLPRALAFAD-SGATWMHLV
DLDA---AKAGGYTLAPLLRQMTRAT---GLQVQTGGGVRSRDDVARI-----------L
D-AGAARVVIGS-----LAVRESA-------------RVIEWLQAFGPERITVALDTRQD
A-----------------------GGVWRLPVHGWTEV----AEATLDVLAQQYAAAGL-
RHLLCTDIARDGMLSGPNMDVYTYLRALVP---AVQLQVSGGARDVADVVAAKMA---G-
--CAGIVLGKA--LLEGRLALKEAVQQGSVADPSDPLPCGELTEPVCR
>hisA-Campylobacter [Campylobacter jejuni] (Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae; Campylobacter; jejuni)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MTQIIPALDL--
--IDGE--VVRLVK------GDYEQKKVYKYN--------PLKKFKEYEK-AGAKELHLV
DLTG---AKDPSKRQFALIEKLAKEV---SVNLQVGGGIRSKEEVKAL-----------L
D-CGVKRVVIGS-----MAIKDAT-------------LCLEILKEFGSEAIVLALDTILK
E-------------------------DYVVAVNAWQEA----SDKKLMEVLDFYSNKGL-
KHILCTDISKDGTMQGVNVRLYKLIHEIFP---NICIQASGGVASLKDLENLKGI-----
--CSGVIVGKA--LLDGVFSVEEGIR--CLAN----------------
>hisA-Buchnera [Buchnera aphidicola (Acyrthosiphon pisum)] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera; aphidicola)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MIIPAFDL--
--INGR--TVRLYQ------GDYSNQKNYNVN--------LFNSLEVYKS-KGIEIVHLV
DLDG---AKNSANRQIELFKKIVSHT---TVPVQVGGGIRTTKDISTL-----------L
D-LGVKRVVIGS-----SIVSNKK-------------QVKQWLNFYGPDAIVLALDVHVD
G-----------------------SNKKEISIDGWQKK----TNFILEEIIEYFLSSGL-
KHVLCTDISRDGTLLGPNFKLYKEICSNFK---NINFQASGGVASLQDIIFLKKT---G-
--VKSIIIGRS--LLEKKFTIEEAVK--CWQRES--------------
>hisA-Yersinia [Yersinia pestis] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Yersinia; pestis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MIIPALDL--
--IEGK--VVRLHQ------GDYGQQRDYGNH--------PLPRLQDYQQ-QGAQVLHLV
DLTG---AKDPAARQIPLLRELLAGV---DVPVQVGGGIRNEQDVVAL-----------L
E-AGAARVVVGS-----TAVKQPE-------------MVQQWFERYGAEAIVLALDVRIN
E-----------------------AGCKHVAISGWQEN----SDATLEQIVEQYLPYGL-
KHVLCTDISRDGTLSGSNVELYQEVCQRYP---QVAFQASGGIGCLDDIARLRGS---G-
--VQGVIVGRA--LLDGKFNVKEAIA--CWQNV---------------
>hisA-Salmonella [Salmonella typhimurium] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella; typhimurium)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MIIPALDL--
--IDGT--VVRLHQ------GDYARQRDYGND--------PLPRLQDYAA-QGAGVLHLV
DLTG---AKDPAKRQIPLIKTLVAGV---NVPVQVGGGVRTEEDVAAL-----------L
K-AGVARVVIGS-----TAVKSPD-------------VVKGWFERFGAQALVLALDVRID
E-----------------------HGTKQVAVSGWQEN----SGVSLEQLVETYLPVGL-
KHVLCTDISRDGTLAGSNVSLYEEVCARYP---QIAFQSSGGIGDIDDIAALRGT---G-
--VRGVIVGRA--LLEGKFTVKEAIQ--CWQNV---------------
>hisA-Escherichia1 [Escherichia coli O157:H7 str. Sakai] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia; coli)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MMIIPALDL--
--IDGT--VVRLHQ------GDYGKQRDYGND--------PLPRLQDYAA-QGAEVLHLV
DLTG---AKDPAKRQIPLIKTLVAGV---NVPVQVGGGVRSEEDVAAL-----------L
E-AGVARVVVGS-----TAVKSPE-------------MVKGWFERFGADALVLALDVRID
E-----------------------QGNKQVAVSGWQEN----SGVSLEQLVETYLPVGL-
KHVLCTDISRDGTLAGSNVSLYEEVCARYP---QVAFQSSGGIGDINDVAALRGT---G-
--VRGVIVGRA--LLEGKFTVKEAIS--CWQNA---------------
>hisA-Escherichia2 [Escherichia coli O157:H7 EDL933] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia; coli)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MMIIPALDL--
--IDGT--VVRLHQ------GDYGKQRDYGND--------PLPRLQDYAA-QGAEVLHLV
DLTG---AKDPAKRQIPLIKTLVAGV---NVPVQVGGGVRSEEDVAAL-----------L
E-AGVARVVVGS-----TAVKSPE-------------MVKGWFERFGADALVLALDVRID
E-----------------------QGNKQVAVSGWQEN----SGVSLEQLVETYLPVGL-
KHVLCTDISRDGTLAGSNVSLYEEVCARYP---QVAFQSSGGIGDINDVAALRGT---G-
--VRGVIVGRA--LLEGKFTVKEAIS--CWQNA---------------
>hisA-Escherichia3 [Escherichia coli K12] (Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia; coli)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MMIIPALDL--
--IDGT--VVRLHQ------GDYGKQRDYGND--------PLPRLQDYAA-QGAEVLHLV
DLTG---AKDPAKRQIPLIKTLVAGV---NVPVQVGGGVRSEEDVAAL-----------L
E-AGVARVVVGS-----TAVKSQD-------------MVKGWFERFGADALVLALDVRID
E-----------------------QGNKQVAVSGWQEN----SGVSLEQLVETYLPVGL-
KHVLCTDISRDGTLAGSNVSLYEEVCARYP---QVAFQSSGGIGDIDDVAALRGT---G-
--VRGVIVGRA--LLEGKFTVKEAIA--CWQNA---------------
>hisA-Vibrio [Vibrio cholerae] (Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; cholerae)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MIIPALDL--
--IEGQ--VVRLYQ------GDYGQVTEYKVD--------PAEQFNLYHQ-AGAGWLHLV
DLTG---AKNTAARQLNLIARLLAST---PANIQIGGGVRSEQDVVDL-----------L
E-AGAQRVVVGS-----TAVKQPQ-------------LVKSWIEKYGAEKIVLALDINID
E-----------------------QGTRKVAISGWQED----SGVTIEALIDDYLTVGL-
QHVLCTDISRDGTLAGSNVELYRDLCRQYP---QVQFQSSGGIGSLADIEALKGT---G-
--VAGVIVGRA--LLDGKFTAQEAFA--CWQNG---------------
>hisA-Haemophilus [Haemophilus influenzae] (Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus; influenzae)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MKQSIIIPALDL--
--INGQ--VVRLHQ------GDYAKQTTYSDN--------PIKQFDNYVR-QGAKQLHLV
DLTG---AKNPQSRQTALIGKIVEAT---QCKVQVGGGIRTEQDVADL-----------L
A-VGANRVVIGS-----TAVTHRS-------------MVKNWFIKYGAEKFVLALDVNIN
A-----------------------SGQKIVAISGWQEE----SGVLLETLIEDFQTVGL-
QQVLCTDISRDGTLTGSNIGLYQEICEKYP---PIQFQSSGGIGSLADIEALKGT---G-
--VSGVIVGRA--LLEGKFTLSEAIK--CWQNG---------------
>hisA-Pasteurella [Pasteurella multocida] (Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Pasteurella; multocida)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MKTSQIIPALDL--
--IDGQ--VVRLYQ------GDYGQKTLYSDN--------PIAQFQDYVA-QGAKYLHLV
DLTG---AKDPTKRQTQLIGEIINAV---NCSIQVGGGIRTEQDVADL-----------L
A-VGANRVVIGS-----TAVKQPE-------------MVKQWFKKYGAEKFVLALDVNIN
A-----------------------QGEKQIAVSGWQEN----SGVSLEALIADFREVGL-
QHVLCTDISKDGTLQGSNVALYQEICTQFP---TIQFQSSGGIGSIADIDALKGT---G-
--VAGVIVGRA--LLEGKFNVQEAIA--CWQNA---------------
>hisA-Aquifex [Aquifex aeolicus] (Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex; aeolicus)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MNLKEFIIPAIDL--
--MEGK--AVRLYK------GDFNKVKVYSER--------PWELAKNFSD-LGFKRLHVV
DLEG---AEGGKPKNLEVIRKIRENF---EGEVEVGGGIRSYEVAKAL-----------F
D-EGIDFVVIGT-----LAYKNKE-------------EFLKILENF-PNRVILAIDSK--
-------------------------QGK-VAIGGWKEE----TAVSPEEFAKEYENYPI-
WGYLYTVIERDGSLEGVDVEPYKEIKKHV----KKPVIASGGVSSLEDIKKLYGI-----
--VEGVVVGKA--IYEGRITLEDLQN--F-------------------
>hisA-Methanopyrus [Methanopyrus kandleri] (Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae; Methanopyrus; kandleri)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MAFVVIPSVDV--
--VEGK--CVQLVE------GDPERRTFESDD--------PVETAHQWSE-F-FPWIHVV
DVDA---AR-GEGDNSDIIGRICEEV---DAKVQVGGGIRSAERAEEL-----------I
E-LGADRLIVGT-----VAFTDKDDFS----------KIVDVCHDHGIE-VFVALDVN--
-------------------------ENHEVLVSGWKED----AGVTLEDAIERFNEV-A-
DGYLTTAVHVEGKEMGIDEKVVEKSTGAT----DLPVLYAGGIASIKDVKRAKEA---G-
--AYGVVIGTA--LYHGDIDPVALLD--LMEED---------------
>hisA-Corynebacterium [Corynebacterium glutamicum] (Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium; glutamicum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MTFTILPAVDV--
--VNGQ--AVRLDQ------GEAGTEKSYGT---------PLESALKWQE-QGAKWLHFV
DLDA---AF-NRGSNHEMMAEIVGKL---DVDVELTGGIRDDESLERA-----------L
A-TGARRVNIGT-----AALEKPE-------------WIASAIQRYG-EKIAVDIAVRLE
D------------------------GEWRTRGNGWVSD-----GGDLWEVLERLDSQGC-
ARFVVTDVSKDGTLSGPNVELLREVAAAT----DAPIVASGGISVLEDVLELAKYQDEG-
--IDSVIIGKA--LYEHKFTLEEALA--AVEKLG--------------
>hisA-Mycobacterium1 [Mycobacterium leprae TN] (Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; leprae)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MMSLILLPAVDV--
--VEGR--AVRLVQ------GKAGSENDYGS---------ALDAALCWQR-DGADWIHLV
DLDA---AF-GRGSNRELLSEMVGKL---DVQVELSGGIRDDDSLNAA-----------L
A-TGCARVNLGT-----AACENPH-------------WCAQVIAEHG-DKIAVGLDVQIV
D------------------------GQHRLRGRGWETD-----GGDLWDVLENLDRQGC-
SRFIVTDVTKDGTLDGPNLDLLASVSDRT----NVPVIASGGVSSLDDLRAIAKFTERG-
--IEGAIVGKA--LYAERFTLPQALA--VVRM----------------
>hisA-Mycobacterium2 [Mycobacterium tuberculosis] (Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium; tuberculosis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MPLILLPAVDV--
--VEGR--AVRLVQ------GKAGSQTEYGS---------AVDAALGWQR-DGAEWIHLV
DLDA---AF-GRGSNHELLAEVVGKL---DVQVELSGGIRDDESLAAA-----------L
A-TGCARVNVGT-----AALENPQ-------------WCARVIGEHGDQ-VAVGLDVQII
D------------------------GEHRLRGRGWETD-----GGDLWDVLERLDSEGC-
SRFVVTDITKDGTLGGPNLDLLAGVADRT----DAPVIASGGVSSLDDLRAIATLTHRG-
--VEGAIVGKA--LYARRFTLPQALA--AVRD----------------
>hisA-Mycobacterium3 [Mycobacterium tuberculosis H37Rv] (Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; tuberculosis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MMPLILLPAVDV--
--VEGR--AVRLVQ------GKAGSQTEYGS---------AVDAALGWQR-DGAEWIHLV
DLDA---AF-GRGSNHELLAEVVGKL---DVQVELSGGIRDDESLAAA-----------L
A-TGCARVNVGT-----AALENPQ-------------WCARVIGEHGDQ-VAVGLDVQII
D------------------------GEHRLRGRGWETD-----GGDLWDVLERLDSEGC-
SRFVVTDITKDGTLGGPNLDLLAGVADRT----DAPVIASGGVSSLDDLRAIATLTHRG-
--VEGAIVGKA--LYARRFTLPQALA--AVRD----------------
>hisA-Archaeoglobus [Archaeoglobus fulgidus] (Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus; fulgidus)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MFRVIPAIDL--
--KDGK--VVRLRQ------GKEDEVTFEATN--------PIEVAKQWVE-IGAKVLHVI
DLSG---AFQGRLRHEEIIAEIAKMA-----EVQVGGGIRDFRVAERL-----------F
E-LGVDRVIFGT-----IAVERVE-------------ELREFAKKW-KGRVMVAIDSK--
-------------------------KGR-VAVKGWKEV----VELTPVQLAELYDDLDV-
-SFLYTNIDVEGLVSGIERERIEEVVKSL----RNPVYVAGGISSIEDIRFAKRV---G-
--AAGVVIGSA--LYTKKLKFEEAIK--VEYEKV--------------
>hisA-Deinococcus [Deinococcus radiodurans] (Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae; Deinococcus; radiodurans)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MTLPLPQVIPCVDI--
--QSGR--AVRLYE------GDPDRETVYFDS--------PRAAARHWVT-LGAGFLHLV
DLDA---AT-GRGENRAVIAEIVREL---GVPVEVGGGVRDRAAAQSL-----------L
T-AGVARVVIGT-----AAVRNPE-------------LVAELIAEYGPERVVVSLDAR--
--------------------------GLEVATHGWAAG----SGVSVADLTPRLAEAGL-
RTLIFTDVTRDGTLRGLDRDLMRQVRGLW----HGELIVGGGVADTNDVRLLAEE---G-
--IEGAIVGRA--IYEGTLPYPVRL-----------------------
>hisA-Methanocaldococcus [Methanocaldococcus jannaschii] (Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus; jannaschii)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MIIIPAVDL--
--KDKK--CVQLIQ------GDPNKKHLELNN--------PVEVAKKFVD-EGAEYLHII
DLDA---AF-GTGNNRDVIKNIIKEV---NVPVEVGGGIRNLEIAKEL-----------I
S-LGVDRVIVGT-----KAILEPK-------------FIDDLNKEIGKDKIVLAVECK--
--------------------------EGKVVIKGWKEK----VDKTPIEVIKEFEDK-V-
GYILFTNVDVEGLLKGINVDIIKELIEKT----DIPIIYSGGITTLEDIKALKEL---G-
--IYGVVIGSA--LYKGLIDLKKALE--IVKN----------------
>hisA-Halobacterium [Halobacterium salinarum] (Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Halobacterium; salinarum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MTFESFTVLPAVDM--
--QDGQ--VVQLVQ------GERGTERTYGD---------PVDAATDWVA-AGAEALHLV
DLDG---AFEGARANATAVEDILDAT---DVSVQVGGGIRSAEDATAL-----------L
D-RGVDRVILGT-----AAIETPD-------------IVGEIAAAY-SDGVLVSLDAK--
--------------------------DGEVVVEGWTEG----TGMDPVAAAQRYADLGA-
AGILFTDVDVEGKQEGVRTDPVRDLVDSV----DIPVIASGGVATVDDVRALEAA---G-
--AAGAVVGTA--LYEGNFTLADAQA--AVED----------------
>hisA-Methanothermobacter [Methanothermobacter thermautotrophicus str. Delta H] (Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter; thermautot.)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MHTTFTFHLYPWILKYLKGGEGNFKYLHQENPKQEITDSSDKMSFWKDRMLIIPAVDI--
--KDGK--CVQLVQ------GKPGTEQVVLDD--------PAGVAGRWES-LGAETIHVV
DLDG---AL-GLEKNTGILKEITERV---SVPLQIGGGIRSREYAGKL-----------L
D-MGFERVILGT-----MAIENPA-------------IVEELAGEYGSERIMVSLDSR--
--------------------------DSRVVIRGWTEK----VPFTAEEMARKFQERGA-
GSILFTNVDFEGLLSGFDLKPVSELVEAV----EIPVIYSGGVSSLNDLRMLQGT---G-
--VMGVVIGSA--IYRGLIDLTEALK--YQDLK---------------
>hisA-Methanosarcina [Methanosarcina acetivorans] (Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; acetivorans)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MAFEVIPAVDM--
--RGGK--CVQLVQ------GVPGSEIVSLND--------PLAVALDWIG-KGAKTLHLV
DLDG---AIEGERKNAPIIEKIVQACREKGVSIQVGGGIRSFEDAASL-----------L
E-LGVSRIILGT-----AALQNPE-------------LVKQLSDAFGSSCVNVALDAK--
--------------------------NGKISIKGWTEE----CAQTPVEMGREFEELGA-
GSLLFTNIDTEGLMQGVNPGPTRELVESV----SIPVIASGGVSSLEDLKVLKQT---G-
--ASGVVVGSA--LYTGRFTLEAAIE--TIRND---------------
>hisA-Lactococcus [Lactococcus lactis subsp. lactis] (Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus; lactis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MKIIPAIDL--
--QNGE--AVRLYK------GDYDKKTVYSKT--------PLEIAQKFER-MGATDLHLV
DLDD---ANIGQTRNLEIVRKIKEET---RLKIEIGGGIRDFDTVRMY-----------L
EQIGVERVILGT-----AAVEKPD-------------FLKELLIKYGPSKIIVGVDIR--
-------------------------EGF-VSTSGWLEK----TSLPYLSFLKKLERIGV-
KTTIITDISKDGTLTGPNFKLYDEISKES----SLNVIISGGVKDNSDIQRATRS---D-
--FYGIIVGKA--YYEKKINLEKEFR--NAN-----------------
>hisA-Clostridium [Clostridium acetobutylicum] (Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; acetobutylicum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MIILPAIDI--
--KQGK--CVRLYQ------GRFEKSSVVAES--------PALTAKSFEN-DGAKYIHVV
DLDG---ALEGEIINLDAVKSIVQVT---SVPIELGGGIRNIKVVEKL-----------I
N-IGVKRIILGT-----AALKDKE-------------FTREAIKEYG-KSIAVGIDAK--
-------------------------DGY-VAVNGWLNV----SKINYIEFAKIMEDMGT-
EDIILTDISKDGTLKGPNFDMLKKLQENV----NCNITASGGIKDLDDLIKLKEM---N-
--IYGAIVGKA--IYSEKINLKEAIA--VIEKR---------------
>hisA-Listeria [Listeria innocua] (Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria; innocua)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MQIFPAIDL--
--KNGQ--CVRLFQ------GDFSKKIIVNED--------PIAQAKSFAK-SGATYLHIV
DLDG---ALEGRPVNLEIIQQMKKAA---KVPVQVGGGIRSMAQIDYY-----------L
Q-SGIDRVIIGS-----AALTDPD-------------FLQAAVKKYGSK-IAAGIDAK--
-------------------------NGF-VATSGWLNI----SQVSFLDLAKQMEAMDV-
ETIIYTDISRDGTLTGPNLEQMAALQKHV----TINLIASGGVSSRADLEALSEL---G-
--LYGAIAGKA--LYNGNISMSDIVE--VEQSAY--------------
>hisA-Bacillus1 [Bacillus halodurans] (Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; halodurans)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MAKFIIYPAIDM--
--RDGK--CVRLVQ------GDYNQETVYGDS--------PFTMAKSFAE-QGAEWIHMV
DLDG---AKAKERMNHEHVVKVATEL---DVNVQVGGGIRTAEDIAYY-----------L
D-RGISRVILGS-----VAVNNPA-------------FTKEMLQKYGGEKIAIGLDAR--
-------------------------DGY-VATEGWLET----SSVKAETLGQELARHGA-
EVFIFTDISRDGMLSGPNTEAIVQLAKAT----GKQVIASGGVSSLQDLDALRNEKQNG-
--IAGAIVGKA--LYTNQFTLEDALK--EES-----------------
>hisA-Bacillus2 [Bacillus subtilis] (Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; subtilis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MSAFTLYPAIDM--
--RNGK--CVRLVQ------GDYNKETIYGDS--------PYDMAELFEK-EGAEWIHLV
DLDG---AKEGKRVNDRHVIEIAQKL---NLKVEIGGGIRSENDVYEY-----------L
S-AGVERVILGS-----SAVSNPP-------------FVKKMLKQYG-EKIAIGLDAR--
-------------------------NGF-VSTEGWLET----STLKATELGKELANEGA-
EVFIFTDIATDGMLSGPNVKSTVELAKET----GKSVIASGGVSSVADLEALARNEADG-
--VSGAIIGKA--LYTNQFTLSEALE--RVKRK---------------
>hisA-Nostoc [Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)] (Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc; sp.)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MDVIPAIDL--
--LAGR--CVRLYQ------GDYDRSQVFSEN--------PVDVAKQWVD-EGATRLHIV
DLDG---AKAGKVVNLGAIEAIAQAI---SIPIEIGGGLRDRSSVEQV-----------F
N-LGVQWAILGT-----VAVEQPQ-------------LVQELCQQY-PGQIIIGIDAR--
--------------------------NGLVATRGWLET----SEVLATQLAIQMQEMGA-
AAIIYTDIHRDGTLAGPNLDALRELAAAI----SIPVIASGGVSSVTDLLSLLALEPQG-
--VTGVIVGRA--LYTGDISLKEALQ--AIGPGRIQDIPPNLDFSSFA
>hisA-Synechocystis [Synechocystis sp. PCC 6803] (Bacteria; Cyanobacteria; Chroococcales; Synechocystis; sp.)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MKILPAIDL--
--LGGK--CVRLYQ------GDYDQSQVYHED--------PVEVARQWQA-QGASRLHLV
DLDG---AKEGQPVNLTAIANIVEAL---TIPVQVGGGLRDRNRVKQL-----------L
D-LGVGRVILGT-----IAVENPD-------------LVGELCAEF-PGQIVVGIDAR--
--------------------------NGKVATRGWLET----STVEAGELAQRMEKLGA-
AAIIYTDIHRDGTMQGPNLDALRQLASQL----TIPVIASGGVSQVEDLLNLLSLESLG-
--VNGVIIGKA--LYTGDIQLAEAIR--AVGNGRWQDVPPLDFPRLG-
>hisA-Pseudomonas [Pseudomonas aeruginosa] (Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; aeruginosa)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MLIIPAIDL--
--KDGA--CVRLRQ------GLMEDATVFSDD--------PVAMAAKWVD-GGCRRLHLV
DLNG---AFEGKPVNGEVVTAIARRY--PDLPIQIGGGIRSLETIEHY-----------V
R-AGVSYVIIGT-----KAVKQPE-------------FVGEACRAF-PGKVIVGLDAK--
--------------------------DGFVATDGWAEV----SEVQVIDLARRFEADGV-
SAIVYTDISKDGMMQGCNVEATAALANAT----RIPVIASGGIHNLGDIQKLLDARTPG-
--IIGAITGRA--IYEGTLDVAEAQA--LCDNFKA-------------
>hisA-Ralstonia [Ralstonia solanacearum] (Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Ralstonia; solanacearum)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MLLIPAIDL--
--KDGQ--CVRLKQ------GDMDQATVFSED--------PAAMARHWVD-QGARRLHLV
DLNG---AFVGKPRNEAAIKAIIAEV-GSEIPVQLGGGIRDLNTIERW-----------L
D-DGLSYVIIGT-----AAVKNPG-------------FLQDACTAFG-GHIIVGLDAR--
--------------------------DGKVATDGWSKL----TGHEVVDLARKYEDYGV-
ESIIYTDIGRDGMLQGINIDATVKLAQSV----SIPVIASGGLSSLKDIDHLCAVESEG-
--VEGVICGRA--IYSGDLNFREAQD--HADKLGAA------------
>hisA-Neisseria1 [Neisseria meningitidis serogroup A] (Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria; meningitidis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MLLIPAIDL--
--KEGR--CVRLKQ------GLMEEATVFSDS--------PAETALHWFE-QGARRLHLV
DLNG---AFAGVPQNLPAIKDILAAV-AKDIPVQLGGGIRDLKTIGQY-----------L
D-LGLNDVIIGT-----AAVKNPD-------------FVREACKAF-PGRIIVGLDAK--
--------------------------DGMAAIDGWATV----TGHHVIDLAKRFEDDGV-
NSIIYTDIGRDGMMSGVNIDATVKLAQAV----RIPVIASGGLTGLDDIRALCAAEKRG-
--VAGAITGRA--IYEGSIDFAQAQQ--LADSLD--------------
>hisA-Neisseria2 [Neisseria meningitidis serogroup B] (Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria; meningitidis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MLLIPAIDL--
--KEGR--CVRLKQ------GLMEEATVFSDS--------PAETALHWFK-QGARRLHLV
DLNG---AFAGVPQNLPAIKDILAAV-AKDIPVQLGGGIRDLKTIGQY-----------L
D-LGLNDVIIGT-----AAVKNPD-------------FVREACKAF-PGRIIVGLDAK--
--------------------------DGMAAIDGWATV----TGHHVIDLAKRFEDDGV-
NSIIYTDIGRDGMMSGVNIDATVKLAQTV----RIPVISSGGLTGLDDIRALCAAEKHG-
--VAGAITGRA--IYEGSIDFAQAQQ--LADSLD--------------
>hisA-Caulobacter [Caulobacter vibrioides (Caulobacter crescentus)] (Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales; Caulobacteraceae; Caulobacter; vibrioides)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MILYPAIDL--
--KDGQ--CVRLLH------GDMDKATVFNTS--------PADQAQRFVQ-DGFSWLHVV
DLNG---AIEGKSVNTAAVEQILESI---SIPVQLGGGIRTLEGVEAW-----------I
E-AGVSRVILGT-----VAVHDPE-------------LVKKAARLW-PEQIAVAVDVR--
--------------------------DGKVAVDGWTGL----SDLSAIDLSRRFEDAGV-
AALIITDISRDGALTGVNVEGVGELADAV----SIPVIASGGVAAVADIERLKAR---QG
VEIAGAILGRS--LYAGTIKPSEALI--AAAA----------------
>hisA-Mesorhizobium [Mesorhizobium loti] (Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Mesorhizobium; loti)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MILFPAIDL--
--KDGQ--CVRLKH------GDMATATIYNDD--------PAAQAKAFED-QGFEWLHVV
DLNG---AFKGQSVNSAAVGAILKAT---KNPVQLGGGIRTLAQIEDW-----------L
D-RGLARVILGT-----VAVRDPD-------------LVRQACKAF-PGKVAVGIDAK--
--------------------------GGKVAVEGWAEA----SSLGVVELARKFEGAGV-
AAIIYTDIDRDGVLTGINWDATIDLAEAV----SIPVIASGGLASIADIVRMTMP---DA
QKLEGAISGRA--LYDGRIDPAEALA--ILQGRPEAKS----------
>hisA-Brucella [Brucella melitensis] (Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella; melitensis)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MILFPAIDL--
--KDGQ--CVRLKL------GDMDQATIYNED--------PAAQAKAFED-QGFEWLHVV
DLNG---AFAGESVNGTAVEAILKAT---KNPVQLGGGIRTLAHIENW-----------L
S-RGLRRVILGT-----VAVRDPA-------------LVMEACKAF-PGQVAVGIDAK--
--------------------------GGKVAVEGWAEA----SRLGVIELAKKFEGAGV-
AAIIYTDIDRDGVLAGINWDSTLALAEAV----SIPVIASGGLASMEDIRRLATP---EM
RKLEGAISGRA--LYDGRIDPAEALS--VLRAAA--------------
>hisA-Agrobacterium [Agrobacterium tumefaciens str. C58] (Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium; tumefaciens)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MILFPAIDL--
--KDGE--CVRLKL------GDMEQATVYNED--------PGAQAKAFED-QGFEWLHVV
DLNG---AFAGETVNGAAVDAILKST---KNPVQLGGGIRTLDHIEAW-----------L
S-RGLARVILGT-----VAVRDPV-------------LVIEACKRF-PGQVAVGIDAK--
--------------------------GGKVAVEGWAEA----SELGIIELAKRFEGAGV-
AAIIYTDIDRDGILAGINWASTLELADAV----SIPVIASGGLASIDDIKRMLQP---DA
AKLEGAISGRA--LYDGRIDPTEALD---LIKAAKEVRA---------
>hisA-Sinorhizobium [Sinorhizobium meliloti (Rhizobium meliloti)] (Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium; meliloti)
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MILFPAIDL--
--KDGQ--CVRLKL------GDMEQATVYNPD--------PAAQARAFEE-QGFEWLHVV
DLNG---AFAGETVNGAAVDAILKAT---KNPVQLGGGIRTLEHIENW-----------L
S-RGLKRVILGT-----VAVRDPA-------------LVIEACRKF-PGRVAVGIDAK--
-------------------------GGK-VAVEGWAEA----SELGVVELARKFEGAGV-
AAIIYTDIDRDGILTGINWASTLELADAV----SIPVIASGGLASMDDIRRMTEP---DA
QKLEGAISGRA--LYDGRIDPKEALD--LIREARKGKL----------
